KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
|
Home
|
Kinexus
|
Contact
|
Credits
Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PTPN12
All Species:
16.06
Human Site:
T637
Identified Species:
35.33
UniProt:
Q05209
Number Species:
10
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q05209
NP_001124480.1
780
88120
T637
T
V
S
A
A
T
S
T
E
S
I
S
T
R
K
Chimpanzee
Pan troglodytes
XP_519168
792
88529
T649
T
V
S
A
A
T
S
T
E
S
I
S
T
R
K
Rhesus Macaque
Macaca mulatta
XP_001082837
733
82786
L595
S
P
L
F
R
T
P
L
S
F
T
N
P
L
H
Dog
Lupus familis
XP_540396
757
85032
T614
T
V
S
G
A
T
S
T
E
S
I
S
T
R
K
Cat
Felis silvestris
Mouse
Mus musculus
P35831
775
86973
A637
T
V
S
P
A
S
S
A
E
S
A
C
H
R
R
Rat
Rattus norvegicus
NP_476456
766
85965
A628
A
S
A
T
V
S
P
A
S
S
T
E
S
A
C
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001507461
747
83881
T608
S
A
T
V
S
A
A
T
S
T
E
N
I
T
A
Chicken
Gallus gallus
XP_415970
1211
131521
T1058
T
V
S
A
A
T
T
T
E
S
V
S
A
R
K
Frog
Xenopus laevis
NP_001084841
660
74123
S522
L
E
K
G
L
S
V
S
S
G
M
C
K
N
V
Zebra Danio
Brachydanio rerio
NP_956963
570
64484
Q432
E
R
L
A
V
E
I
Q
K
V
A
L
Q
E
G
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_796904
967
106580
Q688
K
L
S
S
G
S
V
Q
S
S
G
S
D
S
R
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
94.5
91.4
88
N.A.
82.8
83.5
N.A.
74.6
48.3
58.2
46.7
N.A.
N.A.
N.A.
N.A.
28.9
Protein Similarity:
100
95.4
92.3
91
N.A.
88.3
88.8
N.A.
81.1
53.5
66.9
57.4
N.A.
N.A.
N.A.
N.A.
44
P-Site Identity:
100
100
6.6
93.3
N.A.
53.3
6.6
N.A.
6.6
80
0
6.6
N.A.
N.A.
N.A.
N.A.
20
P-Site Similarity:
100
100
20
93.3
N.A.
66.6
26.6
N.A.
46.6
93.3
20
13.3
N.A.
N.A.
N.A.
N.A.
46.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
10
10
10
37
46
10
10
19
0
0
19
0
10
10
10
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
19
0
0
10
% C
% Asp:
0
0
0
0
0
0
0
0
0
0
0
0
10
0
0
% D
% Glu:
10
10
0
0
0
10
0
0
46
0
10
10
0
10
0
% E
% Phe:
0
0
0
10
0
0
0
0
0
10
0
0
0
0
0
% F
% Gly:
0
0
0
19
10
0
0
0
0
10
10
0
0
0
10
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
10
0
10
% H
% Ile:
0
0
0
0
0
0
10
0
0
0
28
0
10
0
0
% I
% Lys:
10
0
10
0
0
0
0
0
10
0
0
0
10
0
37
% K
% Leu:
10
10
19
0
10
0
0
10
0
0
0
10
0
10
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
10
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
0
19
0
10
0
% N
% Pro:
0
10
0
10
0
0
19
0
0
0
0
0
10
0
0
% P
% Gln:
0
0
0
0
0
0
0
19
0
0
0
0
10
0
0
% Q
% Arg:
0
10
0
0
10
0
0
0
0
0
0
0
0
46
19
% R
% Ser:
19
10
55
10
10
37
37
10
46
64
0
46
10
10
0
% S
% Thr:
46
0
10
10
0
46
10
46
0
10
19
0
28
10
0
% T
% Val:
0
46
0
10
19
0
19
0
0
10
10
0
0
0
10
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _